Becoming the Bimboy (Bimbo Transformation Story, Gay Alpha Male M/M Romance)

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M. Kilpeläinen, J. Riikonen, M. A. Vlasova, A. Huotari, V.-P. Lehto, J. Salonen, K.-H. Herzig and K. Järvinen, J. Controlled Release, 2009, 137, 166–170 CrossRef PubMed. H. A. Santos, L. M. Bimbo, V.-P. Lehto, A. J. Airaksinen, J. Salonen and J. Hirvonen, Curr. Drug Discovery Technol., 2011, 8, 228–249 CrossRef CAS. S. H. Kim, J. W. Kim, D. H. Kim, S. H. Han and D. A. Weitz, Small, 2013, 9, 124–131 CrossRef CAS PubMed.

R. Karnik, F. Gu, P. Basto, C. Cannizzaro, L. Dean, W. Kyei-Manu, R. Langer and O. C. Farokhzad, Nano Lett., 2008, 8, 2906–2912 CrossRef CAS PubMed. I’m trying to bring a new definition to the word ‘bimbo’, to reclaim the word in a good way,” she says. “The way it is being used today is to empower someone to be in love with themself, almost obsessed, not having to prove their smarts or who they are. Maybe you can be ditsy and bubbly and have fun and not have to prove anything to anyone. It’s getting used to being underestimated and using it to your advantage when, despite your persona, you know your own wisdom. The word doesn’t hurt. Focus on the message.” Tags will be added with each request, originally from Fanfiction.net (hence the first lemon chapter, requested) Bunch of Danganronpa kink requests from my tumblr. Language: English Words: 159,088 Chapters: 80/? Comments: 118 Kudos: 1,119 Bookmarks: 54 Hits: 120,620 Herein, we propose the combination of lipid vesicles with PSi microparticles as a multistage drug delivery system. Using a glass-capillary flow-focusing droplet generation device, 10,36 thermally hydrocarbonized PSi microparticles (THCPSiMPs) 19,23,30,37 were encapsulated within the aqueous cores of water-in-oil-in-water (W/O/W) double emulsion drops with ultrathin shells. Dewetting of the oil from the shell of the double emulsions induced the formation of a lipid bilayer. 10 The presence of THCPSiMPs within the aqueous cores of these lipid vesicles not only provided the vesicles with higher loading capacity for hydrophobic drugs, as a result of the high porosity of the PSi microparticles, but also their synergistic effect endowed the vehicle with a sustained drug delivery capacity.

bimbo

Justin Cord, The Unexpected Evolution of Language: Discover the Surprising Etymology of Everyday Words Hayes Adams Media, Sep 18, 2012 Kogal or, more correctly, kogyaru and ganguro carry similar connotations as a Japanese version of a "valley girl" or bimbo. The term is sometimes associated with men or women who dye their hair blond, indicating that physical attractiveness is more important to them than other, non-physical traits [3] and as an extension to "the dumb blonde" stereotype. [3] Politics [ edit ]

A buy-in management buyout (BIMBO) occurs when an outside management team joins a company (buying-in) while also buying out the existing management team. As with all newbies, I started on general TikTok: dance routines, funny home videos, viral skits and pet videos. Fig. 5 Flow cytometric analysis of the cellular association of UnTHCPSi and UnTHCPSi–HA + nanoparticles with MDA-MB-231 and MCF-7 breast cancer cells. The cells were incubated with UnTHCPSi and UnTHCPSi–HA + nanoparticles at the concentrations of 50 and 100 μg mL −1 for 6 h at 37 °C. An enhanced association of the UnTHCPSi nanoparticles with both cell lines was observed after the biofunctionalization with HA +.The modern-day bimbo is a fresh approach to intersectional feminism. There is, actually, careful thought behind bimbology, and it could be a way to reach true liberation. Fig. 1 (A) TEM images of the UnTHCPSi and UnTHCPSi–HA + nanoparticles. Scale bars are 100 nm. (B) Colloidal stability of UnTHCPSi and UnTHCPSi–HA + after incubation in HEPES buffer (pH 7.4) at room temperature for 4 h. (C) FTIR absorbance spectra of HA (a), HA + (b), UnTHCPSi–HA + (c), and UnTHCPSi (d). The relevant features of each spectrum are highlighted and numbered for clarity (see text for details). D. Liu, H. Zhang, B. Herranz-Blanco, E. Mäkilä, V. Lehto, J. Salonen, J. Hirvonen and H. A. Santos, Small, 2014, 10, 2029–2038 CrossRef CAS PubMed. B. Guan, S. Ciampi, G. Le Saux, K. Gaus, P. J. Reece and J. J. Gooding, Langmuir, 2011, 27, 328–334 CrossRef CAS PubMed.

H. A. Santos, L. M. Bimbo, V. P. Lehto, A. J. Airaksinen, J. Salonen and J. Hirvonen, Curr. Drug Discovery Technol., 2011, 8, 228–249 CrossRef CAS. J. Salonen, A. M. Kaukonen, J. Hirvonen and V.-P. Lehto, J. Pharm. Sci., 2008, 97, 632–653 CrossRef CAS PubMed.The TEM images elucidated that the association and internalization of the bare UnTHCPSi nanoparticles with both cell lines was negligible, which can be possibly explained by the negative charge, as well as by the deficient colloidal stability of these nanoparticles. In contrast, when functionalized with HA +, and despite the less pronounced negative ζ-potential, the nanoparticles were massively associated with the cell membrane and further internalized by both MDA-MB-231 and MCF-7 cells, after which they seemed to be mainly enclosed in the endosomes of the cells. Although the aforementioned improved colloidal stability of UnTHCPSi–HA + nanoparticles favors their internalization by the cancer cells, the HA +-mediated targeting of CD44 receptor might be a driving force for the enhanced interaction and internalization of the nanoparticles by the breast cancer cells. These results represent clear evidence of the enhanced cellular association of UnTHCPSi–HA + when compared with bare UnTHCPSi nanoparticles. Flow cytometric analysis of CD44 expression and cellular association The expression of CD44 receptor in both MDA-MB-231 and MCF-7 breast cancer cells was evaluated by flow cytometry, after staining the cells with PE-CF594-labeled anti-human CD44 antibody (ESI, Fig. S2 †). When compared with the respective negative controls, both the cell lines studied were shown to express the CD44 receptor, as elucidated by the increase in the mean fluorescence intensity of the stained cells. However, the incubation of MCF-7 cancer cells with up to 4-fold increased anti-human CD44 antibody concentration was not reflected by the intensification of the mean fluorescence intensity, which experienced an approximately 9-fold increase in comparison with unstained cells regardless of the antibody concentration, thus indicating the saturation of the receptors promptly available for interacting with the complementary antibody. In contrast, in the case of MDA-MB-231 cancer cells, the successive increase of the anti-human CD44 antibody concentration resulted in the consecutive intensification of the fluorescence signal up to approximately 670-fold compared to the controls, suggesting significantly higher levels of CD44 expression in MDA-MB-231 than in MCF-7 breast cancer cells. 50