Sublingual Vitamin B12 | Powder B12 Supplement | Highly Absorbable | 50g Powder | G&G Vitamins

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Vegans and vegetarians. Since most food sources of B12 are animal products, vegans and vegetarians have a higher risk of deficiency. While there are vegan foods fortified with B12, like nutritional yeast, B12 supplements could be another way for plant-based eaters to prevent deficiency.

The natural forms of B12 are called methylcobalamin, adenosylcobalamin, and hydroxycobalamin. These forms have a greater bioavailability (absorption) and are considered the preferred form in supplements. However, the synthetic cyanocobalamin form can still be used for B12 supplements especially if absorption is not an issue. Paul C, Brady DM. Comparative bioavailability and utilization of particular forms of B(12) Supplements with potential to mitigate B(12)-related genetic polymorphisms. Integr Med 2017;16:42-9. [ PubMed abstract]Estourgie-van Burk GF, van der Kuy PHM, de Meij TG, Benninga MA, Kneepkens CMF. Intranasal treatment of vitamin B(12) deficiency in children. Eur J Pediatr 2020;179:349-52. [ PubMed abstract] Thiamin cannot be stored in the body, so you need it in your diet every day. What happens if I take too much thiamin?

Vitamin B12 is an essential vitamin, meaning our bodies don’t produce it on their own, so we must get it from food. Although deficiencies in the U.S. are fairly low, the following groups may benefit from supplementation.Table 1 lists the current RDAs for vitamin B12 [ 1]. For adults, the main criterion that the FNB used to establish the RDAs was the amount needed to maintain a healthy hematological status and serum vitamin B12 levels. For infants age 0 to 12 months, the FNB established an AI that is equivalent to the mean intake of vitamin B12 in healthy, breastfed infants. Table 1: Recommended Dietary Allowances (RDAs) for Vitamin B12 [ 1] Age Schijns W, Homan J, van der Meer L, Janssen IM, van Laarhoven CJ, Berends FJ, et al. Efficacy of oral compared with intramuscular vitamin B-12 supplementation after Roux-en-Y gastric bypass: A randomized controlled trial. Am J Clin Nutr 2018;108:6-12. [ PubMed abstract]

Vitamin B12 can be found in small quantities in foods such as nutritional yeast flakes, which can actually add a nice cheesy taste to foods and can be easily added to dishes like pasta and pizza, though the best thing you can do to ensure you’re getting the right amount is taking a B12 supplement. What are the different forms of B12 available in supplements, and which one is the most effective? Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD. Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr 2015;102:215-21. [ PubMed abstract] UV light can destroy riboflavin, so ideally these foods should be kept out of direct sunlight. How much riboflavin do I need? Djuric D, Jakovljevic V, Zivkovic V, Srejovic I. Homocysteine and homocysteine-related compounds: An overview of the roles in the pathology of the cardiovascular and nervous systems. Can J Physiol Pharmacol 2018;96:991-1003. [ PubMed abstract] Rutjes AW, Denton DA, Di Nisio M, Chong LY, Abraham RP, Al-Assaf AS, et al. Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. Cochrane Database Syst Rev 2018;12:CD011906. [ PubMed abstract]In general, evidence from RCTs does not show that vitamin B12 supplementation alone or with folic acid, vitamin B6, or both for 1 to 2 years improves cognitive function in older adults with or without dementia, mild cognitive impairment, or Alzheimer’s disease, even though supplementation lowers homocysteine levels [ 91-94]. For example, an RCT administered 400 mcg/day folic acid and 500 mcg/day vitamin B12 (B-vitamin group) or a placebo for 2 years to 2,919 adults age 65 and older with homocysteine levels of 12 to 50 mcmol/L [ 93]. Although homocysteine concentrations declined significantly more (by 5.0 mcmol/L) in the supplementation group than in the placebo group (1.3 mcmol/L), cognitive test scores did not differ between groups. A Cochrane Review of vitamin and mineral supplements to maintain cognitive function in cognitively healthy people included 14 studies that compared folic acid, vitamin B12, vitamin B6, or a combination of these supplements to placebo in 27,882 participants, most of whom were age 60 years or older [ 95]. The supplements had little to no effect on global cognitive function when administered for up to 5 years and appeared to have no impact when administered for 5 to 10 years. But in a few cases when people have taken large amounts of vitamin B6, particularly for more than a few months, the effect can be permanent.