Canesflor Vaginal Probiotics | Helps Prevent Recurrence of Vaginal Infections such as Thrush | Clinically Proven - 10 Count (Pack of 1)

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Buggio, L., Somigliana, E., Borghi, A. & Vercellini, P. Probiotics and vaginal microecology: fact or fancy? BMC Women’s Health 19, 25 (2019). Petricevic, L. & Witt, A. The role of Lactobacillus casei rhamnosus Lcr35 in restoring the normal vaginal flora after antibiotic treatment of bacterial vaginosis. BJOG 115, 1369–1374 (2008).

After completing metronidazole treatment, patients received placebo and yogurt with probiotics, respectively (n=36). Latham-Cork, H. C. et al. A novel non-antimicrobial treatment of bacterial vaginosis: An open label two-private centre study. Eur. J. Obstet. Gynecol. Reprod. Biol. 256, 419–424 (2021). VMT uses a similar approach as fecal microbiome transplant (FMT) which has greatly developed in the past decade in the field of gastroenterology, most prominently to treat recurring Clostridioides difficile infections 12. VMT is the process of obtaining vaginal fluid from a donor and administer it into the vagina of a recipient, after thorough testing and minimal processing with the goal of maintaining the viability of the bacteria 68. The mixture of fluid not only includes the microbes from the donor but also potentially cells, bacteriophages, proteins such as cytokines, and metabolites such as lipids and antimicrobial peptides. Recently, a study recruited five patients suffering from recurrent BV and introduced treatment with VMT after an antibiotic regimen 69, 70. Four of five patients had long-term remission after VMT, making it a promising alternative treatment for recurrent BV. Further studies including large, randomized, placebo controlled clinical trials are needed to follow up on VMT. Notably, of the five women included in the VMT study, four became colonized by L. crispatus with a full cure and were symptom-free up to 11 months, although three of the women required three rounds of VMT before achieving sustained remission. A fifth woman was colonized by L. gasseri and had only a partial cure based on clinical criteria. The feasibility of transplanting the vaginal microbiome between women and its protection against BV development is further supported by increasing evidence from women who have sex with women. The interchange of the vaginal microbiome during sex leads to a high level of concordance for a stable vaginal microbiome and a low risk of BV 69, 71. appears to involve an ability to adhere to and to populate the vaginal epithelium and mucin layer, to Anukam, K. et al. Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial. Microbes Infect. 8, 1450–1454 (2006).

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Patients were randomized between a placebo and either of two regiments of double strain Bifilact( ®) probiotics.

Delia P., Sansotta G., Donato V., Frosina P., Messina G., De Renzis C., et al.. (2007). Use of probiotics for prevention of radiation-induced diarrhea. World J. Gastroenterol. 13 ( 6), 912–915. doi: 10.3748/wjg.v13.i6.912 Ilhan Z. E., Ł Collins S, Beigi R, Mellen C, et al. The effect of pessaries on the vaginal microenvironment. Am J Obstet Gynecol. 2015;212(1):60.e1–60.e6. doi:10.1016/j.ajog.2014.07.024. Anderson D. J., Marathe J., Pudney J. (2014). The structure of the human vaginal stratum corneum and its role in immune defense. Am. J. Reprod. Immunol. 71 ( 6), 618–623. doi: 10.1111/aji.12230

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Gambrell R. D., Jr. (1986). The menopause. Invest. Radiol. 21 ( 4), 369–378. doi: 10.1097/00004424-198604000-00017 Verstraelen, H. et al. Longitudinal analysis of the vaginal microflora in pregnancy suggests that L. crispatus promotes the stability of the normal vaginal microflora and that L. gasseri and/or L. iners are more conducive to the occurrence of abnormal vaginal microflora. BMC Microbiol. 9, 116 (2009). Curty G., de Carvalho P. S., Soares M. A. (2019). The role of the cervicovaginal microbiome on the genesis and as a biomarker of premalignant cervical intraepithelial neoplasia and invasive cervical cancer. Int. J. Mol. Sci. 21 ( 1), 222. doi: 10.3390/ijms21010222 Hans, V. & Rita, V. Bacterial vaginosis: an update on diagnosis and treatment. Expert Rev. Anti Infect. Ther. 7, 1109–1124 (2009).

Ma, D., Chen, Y. & Chen, T. Vaginal microbiota transplantation for the treatment of bacterial vaginosis: a conceptual analysis. FEMS Microbiol Lett. 366, fnz025 (2019). Bradshaw, C. S. et al. Efficacy of oral metronidazole with vaginal clindamycin or vaginal probiotic for bacterial vaginosis: randomised placebo-controlled double-blind trial. PLoS One 7, e34540 (2012). Masson, L. et al. Inflammatory cytokine biomarkers of asymptomatic sexually transmitted infections and vaginal dysbiosis: a multicentre validation study. Sex. Transm. Infect. 95, 5–12 (2019).Zhang, Q. et al. Comparative genomics of Lactobacillus crispatus from the gut and vagina reveals genetic diversity and lifestyle adaptation. Genes 11, 360 (2020). Ya, W., Reifer, C. & Miller, L. E. Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double-blind, randomized, placebo-controlled study. Am. J. Obstet. Gynecol. 203, 120.e1–6 (2010).

Czaja, C. A., Stapleton, A. E., Yarova-Yarovaya, Y. & Stamm, W. E. Phase I trial of a Lactobacillus crispatus vaginal suppository for prevention of recurrent urinary tract infection in women. Infect. Dis. Obstet. Gynecol. 2007, e35387 (2007). Austin, M. N., Beigi, R. H., Meyn, L. A. & Hillier, S. L. Microbiologic response to treatment of bacterial vaginosis with topical clindamycin or metronidazole. J. Clin. Microbiol 43, 4492–4497 (2005).Gordillo Altamirano, F. L. & Barr, J. J. Phage therapy in the postantibiotic Era. Clin Microbiol Rev.s 32, e00066–18 (2019). Laue, C. et al. Effect of a yoghurt drink containing Lactobacillus strains on bacterial vaginosis in women—a double-blind, randomised, controlled clinical pilot trial. Benef. Microbes 9, 35–50 (2018). Cohen, C. R. et al. Randomized trial of lactin-V to prevent recurrence of bacterial vaginosis. N. Engl. J. Med. 382, 1906–1915 (2020). Patients who received cisplatin and pelvic radiotherapy were divided into a probiotic group and a placebo group. Did you know that just like our gut, which is populated by beneficial bacteria, so too the urogenital tract of women contains valuable microbiota? 1 These are mostly of the Lactobacillus species (spp. or group) of bacteria, and are responsible for maintaining the health of the vaginal tract. 2 Probiotics containing these beneficial bacteria can be taken orally, but may also be applied locally in a ‘pessary’ form, and can be helpful in maintaining the balance of good bacteria in the vaginal tract. 1-3