ColdZyme Mouth & Throat Spray (Not Nasal Spray) - Cold Virus Treatment & Symptom Relief - Use at First Signs of a Cold - Menthol Flavour 20ml

Product Information

Exposure to any concomitant treatment (including natural health products) that may affect common cold symptoms; immune suppressants/immune stimulants, analgesics/anti-rheumatics, anti-phlogistics, antitussives/expectorants, mouth or throat therapeutics, decongestants, antibiotics, anti-histaminergic drugs, nasal drops/spray or any medication/treatment known to affect common cold symptoms at any dose, expressed as number of days with concomitant treatment during the first 4 days for each subject (based on diary data). Previous clinical and in vitro investigations have supported the efficacy of a glycerol throat spray containing cold-adapted cod trypsin (ColdZyme) against respiratory viruses causing the common cold bycreating a protective mucosal barrier shown to deactivate common cold virus in vitro and decrease pharyngeal rhinovirus load. Design limitations of this trial may have acted to reduce the ability to appreciate differences between placebo and ColdZyme treated groups affecting the primary and major secondary variables. First, the placebo spray containing menthol may have signaled a perception of efficacy in the placebo-treated subjects as sixty percent at the end of the study rated efficacy as “very good” or “good”, thereby lessening differences with active treatment. Do not inhale while spraying as this may cause short-term asthma-like symptoms, such as coughing and hoarseness.

We respect that many of our products are of a sensitive nature - this is why we take every step to keep your purchases private. The first major secondary endpoint was defined as the AUC for the composite daily severity of all symptoms within the Jackson scale assessed during the first 8 days of common cold symptoms (AUC Jackson), based on the daily records (twice per day) for the Jackson scale items in the subjects’ common cold diary. Further, 10% fewer subjects reported WURSS-21 QoL scores greater than zero in the ColdZyme group (p = 0. The investigators’ assessed the efficacy of the investigational product similarly, with ratings “very good” or “good” for 64.This barrier traps the cold virus, disables its ability to bind in to human cells and helps your body to remove them naturally. For calculation of mean, confidence intervals, frequencies and standard deviations, the statistical functions in Excel 2016 were used. Finally, the trypsin enzymes (responsibly sourced from cod as a sustainable biproduct of the fishing industry) deactivates the virus particles, inhibiting them from infecting cells, multiplying and then spreading. The barrier reduces the ability of the virus to bind to the cells in the mucous membrane and cause illness.

Jackson’s symptom scale and the 9-item Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21) quality of life (QoL) domain and a sore throat scale were recorded daily by subjects, as well as any use of allowed rescue treatment. These results support previous findings from a double-blind, placebo-controlled study, where subjects treated with ColdZyme displayed significantly decreased viral load and fewer days with common cold symptoms [10] . ColdZyme ® Mouth Spray (ColdZyme) is intended to reduce the probability of catching a cold and/or can help shorten the duration of a cold, if used at an early stage of the infection, by forming a barrier on the pharyngeal mucous membrane.The outcome of this study supporting a shorter duration of the common cold adds to previous findings in a randomized placebo-controlled study on healthy volunteers treated with ColdZyme, in which a lower oropharyngeal virus load and a reduced duration of common cold symptoms were shown following experimental inoculation with rhinovirus-16 [ 13].